ATP dimagnesium

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ATP (Adenosine 5'-triphosphate) dimagnesium 是体内能量储存和代谢的重要物质，为代谢提供能量，同时在细胞中作为辅酶发挥作用。ATP dimagnesium 是免疫和炎症中重要的内源性信号分子。

ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation.

ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs.ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner.ATP promotes neutrophil chemotaxis in vitro.

ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo.ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo.Animal Model:Four-week-old Kunming mice (18-22 g)Dosage:50 mg/kg Administration: Intraperitoneal injection, before bacterial (E. coli) challenge Result:Protected mice from bacterial infection.

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Other Targets

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74804-12-9

551.76

C10H12Mg2N5O13P3

>98% (HPLC)

In Vitro:?H2O 中的溶解度 : 250 mg/mL (453.10 mM; 超声助溶)

[Mg++].[Mg++].Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O

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(-20℃)

With Ice Pack

≥ 2 years